Calorie Restriction-Like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

Cell Metab. 2011 Nov 2;14(5):612-22. doi: 10.1016/j.cmet.2011.10.002.

Abstract

Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1α protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / drug effects*
  • Adipose Tissue / metabolism
  • Alanine Transaminase / analysis
  • Blood Glucose / analysis
  • Blood Pressure
  • Caloric Restriction / methods*
  • Citrate (si)-Synthase / biosynthesis
  • Cross-Over Studies
  • Double-Blind Method
  • Energy Metabolism / drug effects
  • Fatty Acids / metabolism
  • Glycerol / blood
  • Heat-Shock Proteins / biosynthesis
  • Humans
  • Liver / drug effects*
  • Liver / metabolism
  • Male
  • Middle Aged
  • Mitochondria, Muscle / drug effects*
  • Mitochondria, Muscle / metabolism
  • Muscle, Skeletal / drug effects*
  • Muscle, Skeletal / metabolism
  • Netherlands
  • Obesity / drug therapy*
  • Obesity / metabolism
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Protein Kinases / biosynthesis
  • Resveratrol
  • Sirtuin 1 / biosynthesis
  • Stilbenes / administration & dosage
  • Stilbenes / therapeutic use*
  • Switzerland
  • Transcription Factors / biosynthesis
  • Triglycerides / blood

Substances

  • Blood Glucose
  • Fatty Acids
  • Heat-Shock Proteins
  • PPARGC1A protein, human
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Stilbenes
  • Transcription Factors
  • Triglycerides
  • Citrate (si)-Synthase
  • Alanine Transaminase
  • Protein Kinases
  • AMP-activated protein kinase kinase
  • SIRT1 protein, human
  • Sirtuin 1
  • Glycerol
  • Resveratrol

Associated data

  • GEO/GSE32357