Estimate at your peril: imputation methods for patient withdrawal can bias efficacy outcomes in chronic pain trials using responder analyses

MeSH terms

• Analgesics / adverse effects
• Analgesics / therapeutic use*
• Chronic Pain / drug therapy*
• Chronic Pain / epidemiology
• Clinical Trials as Topic / methods
• Clinical Trials as Topic / standards*
• Clinical Trials as Topic / statistics & numerical data
• Humans
• Pain Measurement / methods
• Pain Measurement / standards
• Pain Measurement / statistics & numerical data
• Patient Compliance* / statistics & numerical data
• Substance Withdrawal Syndrome / epidemiology*