Coupling of osteogenesis and angiogenesis in bone substitute healing - a brief overview

Werner Götz; Christoph Reichert; Luigi Canullo; Andreas Jäger; Friedhelm Heinemann

doi:10.1016/j.aanat.2011.10.002

Coupling of osteogenesis and angiogenesis in bone substitute healing - a brief overview

Ann Anat. 2012 Mar 20;194(2):171-3. doi: 10.1016/j.aanat.2011.10.002. Epub 2011 Oct 14.

Authors

Werner Götz¹, Christoph Reichert, Luigi Canullo, Andreas Jäger, Friedhelm Heinemann

Affiliation

¹ Department of Orthodontics, University of Bonn, Germany. wgoetz@uni-bonn.de

PMID: 22055938
DOI: 10.1016/j.aanat.2011.10.002

Abstract

Similar to osteogenesis and bone repair, the healing and osteogenesis of bone substitutes depend on the osteogenesis-angiogenesis interplay which is controlled by different factors, including VEGF or by hypoxia. A brief review of the process of bone substitute angiogenesis is presented and illustrated by our histological and immunohistochemical findings taken from human biopsies after augmentation with a nanocrystalline synthetic bone substitute.

Publication types

Review

MeSH terms

Bone Substitutes*
Humans
Hypoxia / physiopathology
Immunohistochemistry
Nanoparticles
Neovascularization, Physiologic / physiology*
Osteogenesis / physiology*
Vascular Endothelial Growth Factor A / biosynthesis
Vascular Endothelial Growth Factor A / physiology
Wound Healing

Substances

Bone Substitutes
Vascular Endothelial Growth Factor A