Baroreflex sensitivity is associated with sleep-related breathing problems in adolescents

J Pediatr. 2012 Apr;160(4):610-614.e2. doi: 10.1016/j.jpeds.2011.09.026. Epub 2011 Nov 5.


Objectives: To examine the relationship between sleep-related breathing problems (SRBPs) and baroreflex sensitivity (BRS) among adolescents and assesses whether body mass influences this relationship.

Study design: SRBPs were assessed in 106 adolescents aged 11-14 years using the Pediatric Sleep Questionnaire. Body mass index (BMI) was calculated, and 5 minutes of continuous beat-to-beat blood pressure (Finapres) and R-R interval were recorded (standard electrocardiogram) after 15 minutes of supine rest. Spectral indices were computed using fast Fourier transform, and transfer function analysis was used to compute BRS.

Results: Regression analyses indicate an interaction between BMI and SRBPs (b=-.151, P=.015) on BRS. Graphing the interaction showed that those with higher SRBP scores had lower BRS but that this effect was stronger for those with higher BMI.

Conclusions: Adolescents with elevated SRBP scores had lower BRS. In addition, higher BMI amplified the risk of higher SRBP scores on BRS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Baroreflex / physiology*
  • Body Mass Index
  • Child
  • Female
  • Humans
  • Male
  • Sleep Apnea Syndromes / physiopathology*