Gene expression profiling in adrenocortical neoplasia

Mol Cell Endocrinol. 2012 Mar 31;351(1):111-7. doi: 10.1016/j.mce.2011.09.044. Epub 2011 Oct 25.


Transcriptome studies of adrenocortical tumors have shown clear differences between adenomas and carcinomas and identified two subgroups of carcinomas with different prognoses. This review focuses on how transcriptomes have enriched our knowledge about genes previously identified by classical candidate gene approaches, uncovered novel genes relevant to adrenocortical tumor biology, helped to identify and understand specific pathway alterations, and advanced the overall translational relevance of this field of research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adrenal Cortex Neoplasms* / genetics
  • Adrenal Cortex Neoplasms* / metabolism
  • Adrenal Cortex Neoplasms* / pathology
  • Adrenocortical Adenoma* / genetics
  • Adrenocortical Adenoma* / metabolism
  • Adrenocortical Adenoma* / pathology
  • Adrenocortical Carcinoma* / genetics
  • Adrenocortical Carcinoma* / metabolism
  • Adrenocortical Carcinoma* / pathology
  • Animals
  • Gene Expression Profiling / methods*
  • Gene Expression Regulation, Neoplastic / genetics*
  • Humans