Gene expression profiling in adrenocortical neoplasia

G Assie; T J Giordano; J Bertherat

doi:10.1016/j.mce.2011.09.044

Gene expression profiling in adrenocortical neoplasia

Mol Cell Endocrinol. 2012 Mar 31;351(1):111-7. doi: 10.1016/j.mce.2011.09.044. Epub 2011 Oct 25.

Authors

G Assie¹, T J Giordano, J Bertherat

Affiliation

¹ INSERM U1016, Institut Cochin, Paris, France. guillaume.assie@cch.aphp.fr

PMID: 22056416
DOI: 10.1016/j.mce.2011.09.044

Abstract

Transcriptome studies of adrenocortical tumors have shown clear differences between adenomas and carcinomas and identified two subgroups of carcinomas with different prognoses. This review focuses on how transcriptomes have enriched our knowledge about genes previously identified by classical candidate gene approaches, uncovered novel genes relevant to adrenocortical tumor biology, helped to identify and understand specific pathway alterations, and advanced the overall translational relevance of this field of research.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adrenal Cortex Neoplasms* / genetics
Adrenal Cortex Neoplasms* / metabolism
Adrenal Cortex Neoplasms* / pathology
Adrenocortical Adenoma* / genetics
Adrenocortical Adenoma* / metabolism
Adrenocortical Adenoma* / pathology
Adrenocortical Carcinoma* / genetics
Adrenocortical Carcinoma* / metabolism
Adrenocortical Carcinoma* / pathology
Animals
Gene Expression Profiling / methods*
Gene Expression Regulation, Neoplastic / genetics*
Humans