New insights in the mechanism of microRNA-mediated target repression

Nat Struct Mol Biol. 2011 Nov 4;18(11):1181-2. doi: 10.1038/nsmb.2170.

Abstract

The microRNA-induced silencing complex (miRISC) protein TNRC6 (also called GW182) uses dispersed tryptophan-containing repeats in unstructured regions to recruit the CCR4–NOT nuclease complex leading to mRNA deadenylation and inhibition of translation initiation according to new research.

Publication types

  • News
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Autoantigens / metabolism*
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / physiology*
  • Humans
  • MicroRNAs / metabolism*
  • Multiprotein Complexes / metabolism*
  • RNA-Binding Proteins / metabolism*
  • RNA-Induced Silencing Complex / metabolism*
  • Transcription Factors / metabolism*

Substances

  • Autoantigens
  • CNOT1 protein, human
  • Drosophila Proteins
  • Gw protein, Drosophila
  • MicroRNAs
  • Multiprotein Complexes
  • RNA-Binding Proteins
  • RNA-Induced Silencing Complex
  • TNRC6A protein, human
  • Transcription Factors