Abstract
The microRNA-induced silencing complex (miRISC) protein TNRC6 (also called GW182) uses dispersed tryptophan-containing repeats in unstructured regions to recruit the CCR4–NOT nuclease complex leading to mRNA deadenylation and inhibition of translation initiation according to new research.
Publication types
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News
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Animals
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Autoantigens / metabolism*
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Drosophila Proteins / metabolism*
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Drosophila melanogaster / physiology*
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Humans
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MicroRNAs / metabolism*
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Multiprotein Complexes / metabolism*
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RNA-Binding Proteins / metabolism*
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RNA-Induced Silencing Complex / metabolism*
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Transcription Factors / metabolism*
Substances
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Autoantigens
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CNOT1 protein, human
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Drosophila Proteins
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Gw protein, Drosophila
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MicroRNAs
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Multiprotein Complexes
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RNA-Binding Proteins
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RNA-Induced Silencing Complex
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TNRC6A protein, human
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Transcription Factors