Infants of diabetic mothers with accelerated fetal growth by ultrasonography: are they all alike?

Am J Obstet Gynecol. 1990 Sep;163(3):893-7. doi: 10.1016/0002-9378(90)91091-p.


We studied longitudinal ultrasonographic growth patterns (abdominal circumference, biparietal diameter) initiated early in gestation in 52 pregnancies complicated by pregestational diabetes mellitus and 19 controls. Three predominant patterns of growth were ascertained including a heretofore unrecognized pattern characterized by accelerated abdominal circumference growth (greater than 90th percentile) before 24 weeks' gestational age. Maternal and neonatal anthropometric and metabolic parameters were contrasted for the three patterns. The findings suggest that in some cases of diabetic macrosomia that can be recognized before 24 weeks' gestation, augmented growth may be influenced by factors other than fetal hyperinsulinism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amniotic Fluid / analysis
  • Blood Glucose / analysis
  • Diabetes Mellitus, Type 1 / metabolism
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Embryonic and Fetal Development
  • Female
  • Fetal Macrosomia / diagnosis*
  • Fetal Macrosomia / metabolism
  • Fetal Macrosomia / physiopathology
  • Humans
  • Insulin / analysis
  • Pregnancy
  • Pregnancy in Diabetics / metabolism
  • Pregnancy in Diabetics / physiopathology*
  • Prenatal Diagnosis
  • Ultrasonography*


  • Blood Glucose
  • Insulin