Under pressure: the search for the essential mechanisms of hypertension

Nat Med. 2011 Nov 7;17(11):1402-9. doi: 10.1038/nm.2541.

Abstract

High blood pressure, or hypertension, is a very common disorder with a substantial impact on public health because of its associated complications. Despite the high prevalence of essential hypertension and years of research, the basic causes remain obscure. Here I review recent advances in understanding the pathophysiology of hypertension. I present a general overview of the field and, by necessity, use broad strokes to portray recent progress and place it in context. For this purpose, I use illustrative examples from the large number of important developments in hypertension research over the last five years. The intent of this review is to provide a sense of where the field is progressing, with an emphasis on work that sheds light on pathogenic mechanisms and that is therefore likely to inform new translational advances.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Blood Pressure / physiology*
  • Humans
  • Hypertension / etiology
  • Hypertension / genetics
  • Hypertension / physiopathology*
  • Kidney / physiology
  • Signal Transduction / physiology
  • Skin / metabolism
  • Sodium / metabolism

Substances

  • Sodium