Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment

Pediatrics. 2011 Dec;128(6):e1618-21. doi: 10.1542/peds.2011-0359. Epub 2011 Nov 7.


Standard pharmacologic closure of the patent ductus arteriosus currently involves the administration of 1 of 2 cyclooxygenase inhibitors: either indomethacin or ibuprofen. However, both of these drugs can be associated with potentially significant adverse effects. We present here the cases of 5 preterm infants (gestational age: 26-32 weeks; postnatal age: 3-35 days) with large, hemodynamically significant patent ductus arteriosus who had either failed or had contraindications to ibuprofen therapy. Each of these infants was treated with off-label oral paracetamol (15 mg/kg per dose every 6 hours). Ductal closure was achieved within 48 hours in all the treated infants. No toxicity was observed.

Publication types

  • Case Reports

MeSH terms

  • Acetaminophen / therapeutic use*
  • Ductus Arteriosus, Patent / drug therapy*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male


  • Acetaminophen