Cellular and molecular effects of resveratrol in health and disease

J Cell Biochem. 2012 Mar;113(3):752-9. doi: 10.1002/jcb.23431.

Abstract

Resveratrol, a natural polyphenol abundantly found in grape skins and red wine, possesses diverse biochemical and physiological actions, including anti-inflammatory, anti-oxidation, anti-proliferation and promotion of differentiation, and chemopreventive effects. Recently, it is attracting increased attention due to its health benefits, especially in common age-related diseases such as cardiovascular disease, cancer, type 2 diabetes, and neurological conditions. In this review, we discuss the latest cellular and molecular findings that account for the beneficial actions of resveratrol.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antineoplastic Agents / pharmacology
  • Antioxidants / pharmacology
  • Cardiovascular Diseases / prevention & control
  • Diabetes Mellitus, Type 2 / drug therapy
  • Humans
  • Neurodegenerative Diseases / drug therapy
  • Platelet Aggregation Inhibitors / pharmacology
  • Resveratrol
  • Stilbenes / pharmacology
  • Stilbenes / therapeutic use*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antineoplastic Agents
  • Antioxidants
  • Platelet Aggregation Inhibitors
  • Stilbenes
  • Resveratrol