Hepatoprotective potential of polyphenol rich extract of Murraya koenigii L.: an in vivo study

Food Chem Toxicol. 2012 Feb;50(2):310-4. doi: 10.1016/j.fct.2011.10.063. Epub 2011 Oct 31.


The present study investigates hepatoprotective effects of polyphenol rich Murraya koenigii L. (MK) hydro-ethanolic leaf extract in CCl(4) treated hepatotoxic rats. Plasma markers of hepatic damage, lipid peroxidation levels, enzymatic, and non-enzymatic antioxidants in liver and histopathological changes were investigated in control and treated rats. MK pretreated rats with different doses (200, 400 and 600mg/kg body weight) showed significant decrement in activity levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total protein, and bilirubin. Also, MK treated rats recorded a dose dependent increment in hepatic super oxide dismutase, catalase, reduced glutathione and ascorbic acid and, a decrement in lipid peroxidation. Microscopic evaluations of liver revealed CCl(4)-induced lesions and related toxic manifestations that were minimal in liver of rats pretreated with MK extract. These results demonstrate that hydro-ethanolic leaf extract of MK possesses hepatoprotective potentials.

MeSH terms

  • Animals
  • Carbon Tetrachloride Poisoning
  • Chemical and Drug Induced Liver Injury / prevention & control*
  • Male
  • Murraya / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry
  • Polyphenols / chemistry
  • Polyphenols / pharmacology*
  • Rats


  • Plant Extracts
  • Polyphenols