Attenuated Bordetella pertussis BPZE1 as a live vehicle for heterologous vaccine antigens delivery through the nasal route

Bioeng Bugs. Nov-Dec 2011;2(6):315-9. doi: 10.4161/bbug.2.6.18167. Epub 2011 Nov 1.

Abstract

Whereas the great majority of the current vaccines are delivered through the parenteral route, mucosal administration has been increasingly considered for controlling infection and preventing disease. Mucosal vaccination can trigger both humoral and cell-mediated protection, not only at the targeted mucosal surface, but also systemically. In this regard, nasal vaccination has shown great potential. The live attenuated strain of Bordetella pertussis, BPZE1, is particularly attractive and promising as a nasal vaccine delivery vector of heterologous antigen vaccine candidates. BPZE1 was originally developed as a live nasal pertussis vaccine candidate, and is currently undergoing phase I clinical trial in human (http://www.child-innovac.org). Highly adapted to the human respiratory tract and offering several potential protein carriers for presentation of the heterologous antigen vaccine candidates, BPZE1 represents an appealing platform for the development of live recombinant vaccines delivered via the nasal route that would confer simultaneous protection against pertussis and the targeted infectious disease(s).

Publication types

  • Review

MeSH terms

  • Adhesins, Bacterial / genetics
  • Adhesins, Bacterial / metabolism
  • Administration, Intranasal
  • Animals
  • Antigens, Heterophile* / immunology
  • Bacterial Outer Membrane Proteins / genetics
  • Bacterial Outer Membrane Proteins / metabolism
  • Bordetella pertussis / genetics
  • Bordetella pertussis / immunology*
  • Clinical Trials, Phase I as Topic
  • Drug Delivery Systems / methods*
  • Gene Transfer Techniques
  • Humans
  • Immunity, Mucosal*
  • Mice
  • Nasal Mucosa / immunology
  • Pertussis Vaccine / administration & dosage
  • Pertussis Vaccine / chemistry
  • Pertussis Vaccine / genetics
  • Respiratory System / immunology
  • Vaccination*
  • Vaccines, Attenuated / administration & dosage
  • Vaccines, Attenuated / genetics
  • Vaccines, Attenuated / immunology
  • Vaccines, Synthetic / administration & dosage
  • Vaccines, Synthetic / genetics
  • Vaccines, Synthetic / immunology
  • Virulence Factors, Bordetella / genetics
  • Virulence Factors, Bordetella / metabolism
  • Virus Diseases / immunology
  • Virus Diseases / prevention & control*
  • Virus Diseases / virology
  • Whooping Cough / immunology
  • Whooping Cough / microbiology
  • Whooping Cough / prevention & control*

Substances

  • Adhesins, Bacterial
  • Antigens, Heterophile
  • Bacterial Outer Membrane Proteins
  • BrkA protein, Bordetella pertussis
  • Pertussis Vaccine
  • Vaccines, Attenuated
  • Vaccines, Synthetic
  • Virulence Factors, Bordetella
  • filamentous hemagglutinin adhesin, Bordetella pertussis