On the origin of the triplet puzzle of homologies in receptor heteromers: Toll-like receptor triplets in different types of receptors

Alexander O Tarakanov; Kjell G Fuxe; Dasiel O Borroto-Escuela

doi:10.1007/s00702-011-0734-2

On the origin of the triplet puzzle of homologies in receptor heteromers: Toll-like receptor triplets in different types of receptors

J Neural Transm (Vienna). 2012 May;119(5):517-23. doi: 10.1007/s00702-011-0734-2. Epub 2011 Nov 8.

Authors

Alexander O Tarakanov¹, Kjell G Fuxe, Dasiel O Borroto-Escuela

Affiliation

¹ St. Petersburg Institute for Informatics and Automation, Russian Academy of Sciences, Saint Petersburg, Russia. tar@iias.spb.su

PMID: 22068823
DOI: 10.1007/s00702-011-0734-2

Abstract

Based on our theory, we have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors, which seem to originate from toll-like receptors and appear also as homologies in receptor heteromers. The obtained results strengthen our hypothesis that these triplets may 'guide-and-clasp' receptor-receptor interactions.

Publication types

Comparative Study

MeSH terms

Amino Acid Sequence
Animals
Humans
Molecular Sequence Data
Protein Subunits / chemistry
Protein Subunits / genetics
Receptor Protein-Tyrosine Kinases / chemistry
Receptor Protein-Tyrosine Kinases / genetics
Receptors, G-Protein-Coupled / chemistry
Receptors, G-Protein-Coupled / genetics
Receptors, GABA-A / chemistry
Receptors, GABA-A / genetics
Receptors, Neurotransmitter / chemistry*
Receptors, Neurotransmitter / genetics
Signal Transduction / physiology
Toll-Like Receptors / chemistry*
Toll-Like Receptors / genetics

Substances

GABRB1 protein, human
Protein Subunits
Receptors, G-Protein-Coupled
Receptors, GABA-A
Receptors, Neurotransmitter
Toll-Like Receptors
Receptor Protein-Tyrosine Kinases