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Review
. 2012;127:251-84.
doi: 10.1007/10_2011_117.

Genetic Aspects of Cell Line Development From a Synthetic Biology Perspective

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Review

Genetic Aspects of Cell Line Development From a Synthetic Biology Perspective

L Botezatu et al. Adv Biochem Eng Biotechnol. .

Abstract

Animal cells can be regarded as factories for the production of relevant proteins. The advances described in this chapter towards the development of cell lines with higher productivity capacities, certain metabolic and proliferation properties, reduced apoptosis and other features must be regarded in an integrative perspective. The systematic application of systems biology approaches in combination with a synthetic arsenal for targeted modification of endogenous networks are proposed to lead towards the achievement of a predictable and technologically advanced cell system with high biotechnological impact.

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