A pilot study of nuclear instability in archived renal and upper urinary tract tumours with putative ochratoxin aetiology

Toxins (Basel). 2010 Mar;2(3):326-40. doi: 10.3390/toxins2030326. Epub 2010 Mar 9.


DNA ploidy measurement has been applied uniquely to wax-embedded tissue of primary renal cell and metastatic tumours of a key experimental researcher on porcine ochratoxicosis, a control, and four transitional cell carcinomas from cases of Balkan endemic nephropathy. Primary renal tumour was diploid, and hyperdiploid metastasis was within the lower ploidy range for typical renal cell carcinoma. Three Balkan primary tumours showed extensive aneuploidy indicating marked nuclear instability, similar to model rat renal carcinoma caused by ochratoxin A. In contrast, much less nuclear instability in the putative occupational ochratoxicosis case fitted poorly with the ochratoxin A model.

Keywords: DNA ploidy; Balkan endemic nephropathy; aneuploidisation; metastasis; nuclear instability; ochratoxin A; porcine nephropathy; renal cell carcinoma; transitional cell carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aneuploidy
  • Animals
  • Balkan Nephropathy / etiology*
  • Balkan Nephropathy / pathology
  • Carcinogens / toxicity*
  • Carcinoma, Renal Cell / etiology*
  • Carcinoma, Renal Cell / pathology
  • Carcinoma, Transitional Cell / etiology
  • Carcinoma, Transitional Cell / pathology
  • Cell Nucleus / pathology
  • Female
  • Humans
  • Kidney Neoplasms / etiology*
  • Kidney Neoplasms / pathology
  • Male
  • Middle Aged
  • Ochratoxins / toxicity*
  • Pilot Projects
  • Rats
  • Urologic Neoplasms / etiology*
  • Urologic Neoplasms / pathology


  • Carcinogens
  • Ochratoxins
  • ochratoxin A