Inhibition of hemorragic snake venom components: old and new approaches

Toxins (Basel). 2010 Apr;2(4):417-27. doi: 10.3390/toxins2040417. Epub 2010 Mar 25.

Abstract

Snake venoms are complex toxin mixtures. Viperidae and Crotalidae venoms, which are hemotoxic, are responsible for most of the envenomations around the world. Administration of antivenins aimed at the neutralization of toxins in humans is prone to potential risks. Neutralization of snake venom toxins has been achieved through different approaches: plant extracts have been utilized in etnomedicine. Direct electric current from low voltage showed neutralizing properties against venom phospholipase A2 and metalloproteases. This mini-review summarizes new achievements in venom key component inhibition. A deeper knowledge of alternative ways to inhibit venom toxins may provide supplemental treatments to serum therapy.

Keywords: antivenins; direct electric current; etnomedicine; metalloprotease; phosphodiesterase; phospholipase A2; snake venom.

Publication types

  • Review

MeSH terms

  • Animals
  • Antivenins / pharmacology
  • Electric Stimulation Therapy
  • Hemorrhage / chemically induced*
  • Humans
  • Metalloproteases / antagonists & inhibitors*
  • Phospholipase A2 Inhibitors*
  • Plant Extracts / pharmacology
  • Snake Bites / therapy
  • Snake Venoms / antagonists & inhibitors*
  • Snake Venoms / toxicity

Substances

  • Antivenins
  • Phospholipase A2 Inhibitors
  • Plant Extracts
  • Snake Venoms
  • Metalloproteases