Type VI collagen deficiency induces osteopenia with distortion of osteoblastic cell morphology

Tissue Cell. 2012 Feb;44(1):1-6. doi: 10.1016/j.tice.2011.08.002. Epub 2011 Nov 8.


Bone consists of type I collagen as a major protein with minor various matrix proteins. Type VI collagen is one of bone matrix proteins but its function is not known. We therefore examined the effects of type VI collagen deficiency on bone. 3D-μCT analysis revealed that type VI collagen deficiency reduced cancellous bone mass. Cortical bone mass was not affected. Type VI collagen deficiency distorted the shape of osteoblasts both in the cancellous bone and in the cambium layer of periosteal region. Furthermore, type VI collagen deficiency disorganized collagen arrangement. These data indicate that type VI collagen contributes to maintain bone mass.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Diseases, Metabolic / genetics*
  • Bone Diseases, Metabolic / metabolism
  • Bone Diseases, Metabolic / pathology
  • Bone Remodeling / genetics
  • Bone and Bones / metabolism
  • Bone and Bones / pathology
  • Collagen Type VI / deficiency
  • Collagen Type VI / genetics*
  • Collagen Type VI / physiology
  • Extracellular Matrix / genetics
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microscopy, Polarization
  • Osteoblasts / pathology*
  • Osteoclasts / pathology
  • X-Ray Microtomography


  • Collagen Type VI