Therapies from fucoidan; multifunctional marine polymers

Mar Drugs. 2011;9(10):1731-60. doi: 10.3390/md9101731. Epub 2011 Sep 30.

Abstract

Published research on fucoidans increased three fold between 2000 and 2010. These algal derived marine carbohydrate polymers present numerous valuable bioactivities. This review discusses the role for fucoidan in the control of acute and chronic inflammation via selectin blockade, enzyme inhibition and inhibiting the complement cascade. The recent data on toxicology and uptake of fucoidan is detailed together with a discussion on the comparative activities of fractions of fucoidan from different sources. Recent in vivo, in vitro and clinical research related to diverse clinical needs is discussed. Targets include osteoarthritis, kidney and liver disease, neglected infectious diseases, hemopoietic stem cell modulation, protection from radiation damage and treatments for snake envenomation. In recent years, the production of well characterized reproducible fucoidan fractions on a commercial scale has become possible making therapies from fucoidan a realizable goal.

Keywords: fibrosis; fucoidan; inflammation; viral infection.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Complement Activation / drug effects
  • Dengue / drug therapy
  • Enzyme Inhibitors / therapeutic use
  • Fibrosis / drug therapy
  • Herpesviridae Infections / drug therapy
  • Human T-lymphotropic virus 1 / drug effects
  • Humans
  • Inflammation / drug therapy
  • Influenza, Human / drug therapy
  • Liver Cirrhosis / drug therapy
  • Osteoarthritis / drug therapy
  • Polysaccharides / isolation & purification
  • Polysaccharides / therapeutic use*
  • Polysaccharides / toxicity
  • Radiation-Protective Agents / therapeutic use
  • Seaweed / chemistry
  • Selectins / drug effects

Substances

  • Anti-Inflammatory Agents
  • Enzyme Inhibitors
  • Polysaccharides
  • Radiation-Protective Agents
  • Selectins
  • fucoidan