Molecular biomarker of inflammatory response is associated with rebleeding in spontaneous intracerebral hemorrhage

Eur Neurol. 2011;66(6):322-7. doi: 10.1159/000332027. Epub 2011 Nov 10.


Background and purpose: Rebleeding in spontaneous intracerebral hemorrhage (ICH) is a major cause of morbidity and mortality among stroke survivors. Due to the links between inflammation and rebleeding, we hypothesized that the biomarkers of inflammation are associated with the pathogenesis of rebleeding in ICH. We sought to investigate whether these biomarkers and clinical variables on admission can provide prognostic information on the risk of rebleeding.

Methods: This prospective study enrolled 59 consecutive patients with spontaneous ICH. We determined the concentrations of interleukin-10 (IL-10), intercellular adhesion molecule-1, and complement 3 in blood samples obtained on admission.

Results: Univariate analysis indicated that hematoma volume, leukocyte count, hydrocephalus, and plasma IL-10 levels were associated with rebleeding. Multivariate logistic regression analysis indicated that hydrocephalus (95% CI of OR, 1.6-26.7) and IL-10 (95% CI of OR, 1.03-1.22) were independently associated with an increased probability of rebleeding.

Conclusion: These data suggest that IL-10, a molecular biomarker of inflammatory response in the early acute phase of ICH, is associated with subsequent rebleeding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • Cerebral Hemorrhage / blood*
  • Cerebral Hemorrhage / complications
  • Cerebral Hemorrhage / pathology*
  • Complement C3 / analysis
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Inflammation / blood
  • Intercellular Adhesion Molecule-1 / blood
  • Interleukin-10 / blood
  • Recurrence
  • Risk Factors
  • Stroke / blood
  • Stroke / etiology
  • Stroke / pathology


  • Biomarkers
  • Complement C3
  • Intercellular Adhesion Molecule-1
  • Interleukin-10