A β-resorcylic macrolide from the seagrass-derived fungus Fusarium sp. PSU-ES73

Arch Pharm Res. 2011 Oct;34(10):1633-7. doi: 10.1007/s12272-011-1007-1. Epub 2011 Nov 12.

Abstract

A new β-resorcylic macrolide, 5'-hydroxyzearalenone (1), and six known β-resorcylic macrolides were isolated from the seagrass-derived fungus Fusarium sp. PSU-ES73. Their structures were established by analysis of spectral data. All of the isolated compounds were evaluated for their antibacterial activity against Staphylococcus aureus, both standard and methicillin-resistant strains, as well as their antifungal activity against Cryptococcus neoformans. Only the known compound zearalenone (2) displayed weak antibacterial and antifungal activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alismatales / microbiology*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology*
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Chromatography, Thin Layer
  • Cryptococcus neoformans / drug effects
  • Fermentation
  • Fusarium / chemistry*
  • Indicators and Reagents
  • Macrolides / chemistry
  • Macrolides / isolation & purification*
  • Macrolides / pharmacology*
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Microbial Sensitivity Tests
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared
  • Staphylococcus aureus / drug effects
  • Zearalenone / pharmacology

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Indicators and Reagents
  • Macrolides
  • Zearalenone