Abstract
A new β-resorcylic macrolide, 5'-hydroxyzearalenone (1), and six known β-resorcylic macrolides were isolated from the seagrass-derived fungus Fusarium sp. PSU-ES73. Their structures were established by analysis of spectral data. All of the isolated compounds were evaluated for their antibacterial activity against Staphylococcus aureus, both standard and methicillin-resistant strains, as well as their antifungal activity against Cryptococcus neoformans. Only the known compound zearalenone (2) displayed weak antibacterial and antifungal activities.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alismatales / microbiology*
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / isolation & purification*
-
Anti-Bacterial Agents / pharmacology*
-
Antifungal Agents / chemistry
-
Antifungal Agents / pharmacology
-
Chromatography, Thin Layer
-
Cryptococcus neoformans / drug effects
-
Fermentation
-
Fusarium / chemistry*
-
Indicators and Reagents
-
Macrolides / chemistry
-
Macrolides / isolation & purification*
-
Macrolides / pharmacology*
-
Methicillin-Resistant Staphylococcus aureus / drug effects
-
Microbial Sensitivity Tests
-
Spectrophotometry, Infrared
-
Spectrophotometry, Ultraviolet
-
Spectroscopy, Fourier Transform Infrared
-
Staphylococcus aureus / drug effects
-
Zearalenone / pharmacology
Substances
-
Anti-Bacterial Agents
-
Antifungal Agents
-
Indicators and Reagents
-
Macrolides
-
Zearalenone