Abstract
In this work, 17 new N-acylhydrazone derivatives of amino acids have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. The compounds 8b, 8e, 8f, 9a-d, and 10c exhibited an important minimum inhibitory concentration activity between 12.5 and 50 μg/mL, which can be compared with that of the tuberculostatic drug d-cycloserine (20 μg/mL).
© 2011 John Wiley & Sons A/S.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry*
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Antitubercular Agents / chemical synthesis*
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Antitubercular Agents / chemistry
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Antitubercular Agents / pharmacology*
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Cycloserine / pharmacology
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Hydrazones / chemical synthesis
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Hydrazones / chemistry
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Hydrazones / pharmacology
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects*
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Structure-Activity Relationship
Substances
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Amino Acids
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Antitubercular Agents
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Hydrazones
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Cycloserine