Hyperalgesia by synaptic long-term potentiation (LTP): an update

Curr Opin Pharmacol. 2012 Feb;12(1):18-27. doi: 10.1016/j.coph.2011.10.018. Epub 2011 Nov 9.


Long-term potentiation of synaptic strength (LTP) in nociceptive pathways shares principle features with hyperalgesia including induction protocols, pharmacological profile, neuronal and glial cell types involved and means for prevention. LTP at synapses of nociceptive nerve fibres constitutes a contemporary cellular model for pain amplification following trauma, inflammation, nerve injury or withdrawal from opioids. It provides a novel target for pain therapy. This review summarizes recent progress which has been made in unravelling the properties and functions of LTP in the nociceptive system and in identifying means for its prevention and reversal.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Analgesia / methods*
  • Humans
  • Hyperalgesia / metabolism*
  • Long-Term Potentiation / drug effects*
  • Pain / drug therapy*
  • Signal Transduction / drug effects*