Is corneal deposition of antimalarial any indication of retinal toxicity?

Can J Ophthalmol. 1990 Aug;25(5):249-51.


Ninety-five percent of patients on chloroquine demonstrate corneal deposition of the drug with the pupil dilated; less than 10% of patients on hydroxychloroquine show any corneal changes when so examined. I describe one patient on chloroquine and two on hydroxychloroquine who demonstrated large amounts of corneal antimalarial drug, leading to the early diagnosis of definite retinopathy. Examination of the cornea with the pupil dilated may reveal the presence of retinal toxicity in some patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Chloroquine / adverse effects*
  • Chloroquine / metabolism
  • Cornea / metabolism*
  • Drug Overdose / complications
  • Drug Overdose / diagnosis
  • Female
  • Fluorescein Angiography
  • Fundus Oculi
  • Humans
  • Hydroxychloroquine / adverse effects*
  • Hydroxychloroquine / metabolism
  • Male
  • Pupil / drug effects
  • Retinal Diseases / chemically induced*
  • Retinal Diseases / diagnosis


  • Hydroxychloroquine
  • Chloroquine