Lupus nephritis: current update

Arthritis Res Ther. 2011;13(5):240. doi: 10.1186/ar3378. Epub 2011 Sep 28.


Lupus nephritis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus. The general consensus is that 60% of lupus patients will develop clinically relevant nephritis at some time in the course of their illness. Prompt recognition and treatment of renal disease is important, as early response to therapy is correlated with better outcome. The present review summarizes our current understanding of the pathogenic mechanisms underlying lupus nephritis and how the disease is currently diagnosed and treated.

Publication types

  • Review

MeSH terms

  • Animals
  • Cyclophosphamide / therapeutic use
  • Humans
  • Inflammation Mediators / physiology
  • Lupus Nephritis / diagnosis*
  • Lupus Nephritis / drug therapy
  • Lupus Nephritis / therapy*


  • Inflammation Mediators
  • Cyclophosphamide