PINK1 and Parkin flag Miro to direct mitochondrial traffic

Lesley A Kane; Richard J Youle

doi:10.1016/j.cell.2011.10.028

PINK1 and Parkin flag Miro to direct mitochondrial traffic

Cell. 2011 Nov 11;147(4):721-3. doi: 10.1016/j.cell.2011.10.028.

Authors

Lesley A Kane¹, Richard J Youle

Affiliation

¹ National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.

PMID: 22078873
DOI: 10.1016/j.cell.2011.10.028

Abstract

The Parkinson's disease proteins PINK1 and Parkin are proposed guardians of mitochondrial fidelity, targeting damaged mitochondria for degradation by mitophagy. In this issue of Cell, Wang et al. (2011) now show that PINK1 and Parkin also regulate mitochondrial trafficking and quarantine damaged mitochondria by severing their connection to the microtubule network.

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