Emergence in Japan of an Imipenem-Susceptible, Meropenem-Resistant Klebsiella Pneumoniae Carrying blaIMP-6

Diagn Microbiol Infect Dis. 2012 Jan;72(1):109-12. doi: 10.1016/j.diagmicrobio.2011.09.019. Epub 2011 Nov 10.

Abstract

We identified 5 Klebsiella pneumoniae isolates showing high resistance to β-lactams except imipenem and designated them ISMRK (imipenem-susceptible but meropenem-resistant Klebsiella). They carried the bla(IMP-6) and bla(CTX-M-2) on a self-transmissible plasmid. ISMRK may be falsely categorized as susceptible to carbapenems if imipenem is used to screen carbapenem resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology*
  • Conjugation, Genetic
  • Female
  • Gene Transfer, Horizontal
  • Humans
  • Imipenem / pharmacology*
  • Japan
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / genetics
  • Klebsiella pneumoniae / isolation & purification
  • Male
  • Meropenem
  • Plasmids / analysis
  • Thienamycins / pharmacology*
  • beta-Lactam Resistance*
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Thienamycins
  • Imipenem
  • beta-Lactamases
  • Meropenem