Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease

Neurobiol Aging. 2012 Sep;33(9):1995-2005. doi: 10.1016/j.neurobiolaging.2011.09.026. Epub 2011 Nov 12.


Alzheimer's disease (AD), the most common age-related neurodegenerative disorder, is characterized by the invariant cerebral accumulation of β-amyloid peptide. This event occurs early in the disease process. In humans, [18F]-fluoro-2-deoxy-D-glucose ([18F]-FDG) positron emission tomography (PET) is largely used to follow-up in vivo cerebral glucose utilization (CGU) and brain metabolism modifications associated with the Alzheimer's disease pathology. Here, [18F]-FDG positron emission tomography was used to study age-related changes of cerebral glucose utilization under resting conditions in 3-, 6-, and 12-month-old APP(SweLon)/PS1(M146L), a mouse model of amyloidosis. We showed an age-dependent increase of glucose uptake in several brain regions of APP/PS1 mice but not in control animals and a higher [18F]-FDG uptake in the cortex and the hippocampus of 12-month-old APP/PS1 mice as compared with age-matched control mice. We then developed a method of 3-D microscopic autoradiography to evaluate glucose uptake at the level of amyloid plaques and showed an increased glucose uptake close to the plaques rather than in amyloid-free cerebral tissues. These data suggest a macroscopic and microscopic reorganization of glucose uptake in relation to cerebral amyloidosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / diagnostic imaging
  • Alzheimer Disease / genetics
  • Alzheimer Disease / pathology*
  • Amyloid beta-Protein Precursor / genetics
  • Analysis of Variance
  • Animals
  • Calcium-Binding Proteins / metabolism
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / metabolism*
  • Cerebral Cortex / pathology*
  • Cerebrovascular Circulation / genetics
  • Cerebrovascular Circulation / physiology*
  • Disease Models, Animal
  • Fluorodeoxyglucose F18
  • Glial Fibrillary Acidic Protein / metabolism
  • Glucose / metabolism*
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Microfilament Proteins / metabolism
  • Positron-Emission Tomography
  • Presenilin-1 / genetics


  • Aif1 protein, mouse
  • Amyloid beta-Protein Precursor
  • Calcium-Binding Proteins
  • Glial Fibrillary Acidic Protein
  • Microfilament Proteins
  • PSEN1 protein, human
  • Presenilin-1
  • Fluorodeoxyglucose F18
  • Glucose