Transcriptional networks and chromatin remodeling controlling adipogenesis

Trends Endocrinol Metab. 2012 Feb;23(2):56-64. doi: 10.1016/j.tem.2011.10.001. Epub 2011 Nov 11.


Adipocyte differentiation is tightly controlled by a transcriptional cascade, which directs the extensive reprogramming of gene expression required to convert fibroblast-like precursor cells into mature lipid-laden adipocytes. Recent global analyses of transcription factor binding and chromatin remodeling have revealed 'snapshots' of this cascade and the chromatin landscape at specific time-points of differentiation. These studies demonstrate that multiple adipogenic transcription factors co-occupy hotspots characterized by an open chromatin structure and specific epigenetic modifications. Such transcription factor hotspots are likely to represent key signaling nodes which integrate multiple adipogenic signals at specific chromatin sites, thereby facilitating coordinated action on gene expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipocytes / cytology
  • Adipocytes / metabolism
  • Adipogenesis / genetics
  • Adipogenesis / physiology*
  • Animals
  • CCAAT-Enhancer-Binding Proteins / physiology
  • Cell Differentiation / genetics
  • Chromatin / metabolism
  • Chromatin Assembly and Disassembly / physiology*
  • Gene Regulatory Networks / physiology*
  • Humans
  • PPAR gamma / physiology
  • Signal Transduction
  • Transcription Factors / metabolism


  • CCAAT-Enhancer-Binding Proteins
  • Chromatin
  • PPAR gamma
  • Transcription Factors