Development and applications of destruxins: a review

Biotechnol Adv. Nov-Dec 2012;30(6):1242-54. doi: 10.1016/j.biotechadv.2011.10.006. Epub 2011 Oct 30.

Abstract

The insecticidal and phytotoxic activities of destruxins (dtxs) have been well studied. The cyclodepsipeptides, which are dtxs mainly isolated from the fungus Metarhizium anisopliae and other fungi, have been well characterized in vitro and in vivo. A succession of important function, such as antitumoral, antiviral, insecticidal, cytotoxic, immunosuppressant, phytotoxic, and antiproliferative effects have been observed. To date, 39 dtxs derivatives have been identified. Dtxs possess a variety of biological activities, including acting as virulence factors for specific insects, a V-ATPase inhibitor that provides a basis for the development of new drug to against osteoporosis, cancer, or biological control agents, etc. Here, we focus on some of the research progress made on understanding dtxs during the last decade, introduce some of the newly identified dtx members, especially from M. anisopliae, and give an overview of the applications of dtxs. Using the dtxs to learn about and moderate biological events has advanced significantly during the past year. We believe that several ongoing dtx application fields may benefit from the reviewed information herein.

Publication types

  • Review

MeSH terms

  • Depsipeptides / biosynthesis
  • Depsipeptides / chemistry
  • Depsipeptides / metabolism
  • Depsipeptides / pharmacology*
  • Fermentation / drug effects
  • Metabolic Networks and Pathways / drug effects
  • Pest Control, Biological

Substances

  • Depsipeptides