Retinal nerve fiber layer and macular inner retina measurements by spectral domain optical coherence tomograph in Indian eyes with early glaucoma

Eye (Lond). 2012 Jan;26(1):133-9. doi: 10.1038/eye.2011.277. Epub 2011 Nov 11.


Purpose: To compare the diagnostic abilities of peripapillary retinal nerve fiber layer (RNFL) and macular inner retina (MIR) measurements by spectral domain optical coherence tomography (SD-OCT) in Indian eyes early glaucoma.

Methods: In an observational, cross-sectional study, 125 eyes of 64 normal subjects and 91 eyes of 59 early glaucoma patients underwent RNFL and MIR imaging with SD-OCT. Glaucomatous eyes had characteristic optic nerve and RNFL abnormalities and correlating visual field defects and a mean deviation of better than or equal to -6 dB on standard automated perimetry. Areas under the receiver operating characteristic curves (AUC), sensitivities at a fixed specificity and likelihood ratios (LRs) were estimated for all RNFL and MIR parameters.

Results: The AUCs for the RNFL parameters ranged from 0.537 for the temporal quadrant thickness to 0.821 for the inferior quadrant RNFL thickness. AUCs for the MIR parameters ranged from 0.603 for the superior minus inferior MIR thickness average to 0.908 for ganglion cell complex focal loss volume (GCC-FLV). AUC for the best MIR parameter (GCC-FLV) was significantly better (P<0.001) than that of the best RNFL parameter (inferior quadrant thickness). The sensitivities of these parameters at high specificity of 95%, however, were comparable (52.7% vs58.2%). Evaluation of the LRs showed that outside normal limits results of most of the RNFL and MIR parameters were associated with large effects on the post-test probability of disease.

Conclusion: MIR parameters with RTVue SD-OCT were as good as the RNFL parameters to detect early glaucoma.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Area Under Curve
  • Cross-Sectional Studies
  • Early Diagnosis
  • Female
  • Glaucoma / diagnostic imaging*
  • Glaucoma / epidemiology
  • Glaucoma / pathology
  • Glaucoma / physiopathology
  • Humans
  • India / epidemiology
  • Male
  • Middle Aged
  • Nerve Fibers / diagnostic imaging*
  • Nerve Fibers / pathology
  • Ophthalmic Nerve / diagnostic imaging*
  • Ophthalmic Nerve / pathology*
  • Radiography
  • Reproducibility of Results
  • Retina / diagnostic imaging*
  • Retina / pathology
  • Sensitivity and Specificity
  • Tomography, Optical Coherence*
  • Visual Field Tests