BYKdb: the Bacterial protein tYrosine Kinase database

Nucleic Acids Res. 2012 Jan;40(Database issue):D321-4. doi: 10.1093/nar/gkr915. Epub 2011 Nov 12.


Bacterial tyrosine-kinases share no resemblance with their eukaryotic counterparts and they have been unified in a new protein family named BY-kinases. These enzymes have been shown to control several biological functions in the bacterial cells. In recent years biochemical studies, sequence analyses and structure resolutions allowed the deciphering of a common signature. However, BY-kinase sequence annotations in primary databases remain incomplete. This prompted us to develop a specialized database of computer-annotated BY-kinase sequences: the Bacterial protein tyrosine-kinase database (BYKdb). BY-kinase sequences are first identified, thanks to a workflow developed in a previous work. A second workflow annotates the UniProtKB entries in order to provide the BYKdb entries. The database can be accessed through a web interface that allows static and dynamic queries and offers integrated sequence analysis tools. BYKdb can be found at

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteria / enzymology*
  • Bacterial Proteins / chemistry*
  • Databases, Protein*
  • Molecular Sequence Annotation
  • Protein-Tyrosine Kinases / chemistry*
  • Sequence Analysis, Protein
  • User-Computer Interface


  • Bacterial Proteins
  • Protein-Tyrosine Kinases