Potential use of D-glucaric acid derivatives in cancer prevention

Cancer Lett. 1990 Oct 8;54(1-2):1-8. doi: 10.1016/0304-3835(90)90083-a.


There is now growing evidence from animal models for the possible control of different stages of the carcinogenic process by the beta-glucuronidase inhibitor D-glucaro-1,4-lactone and its precursors such as D-glucaric acid salts, D-glucarates. D-Glucaric acid is a natural, non-toxic compound produced in small amounts by mammals, including humans. It was recently found in some vegetables and fruits. D-Glucaro-1,4-lactone and D-glucarate exhibit potent antiproliferative properties in vivo. Some human subpopulations could have reduced risk of cancer development by ingesting food rich in D-glucaric acid or self-medication with D-glucarates alone or in combination with other chemopreventive agents.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Diet*
  • Glucaric Acid / administration & dosage
  • Glucaric Acid / analogs & derivatives*
  • Glucuronidase / antagonists & inhibitors
  • Humans
  • Neoplasms, Experimental / prevention & control*


  • Glucuronidase
  • Glucaric Acid