Uncovering the Role of 5-hydroxymethylcytosine in the Epigenome

Nat Rev Genet. 2011 Nov 15;13(1):7-13. doi: 10.1038/nrg3080.

Abstract

Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting prospect of a novel epigenetic modification that may dynamically regulate DNA methylation has led to the rapid accumulation of publications from a wide array of fields, from biochemistry to stem cell biology. Although we have only started to scratch the surface, interesting clues on the role of 5-hydroxymethylcytosine are quickly emerging.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 5-Methylcytosine / metabolism
  • Animals
  • Blastocyst Inner Cell Mass / metabolism
  • Cell Differentiation / genetics
  • Cell Proliferation
  • Chromatin / metabolism
  • CpG Islands / physiology
  • Cytosine / analogs & derivatives*
  • Cytosine / metabolism
  • DNA / genetics
  • DNA / metabolism
  • DNA Methylation / genetics
  • DNA-Binding Proteins* / genetics
  • DNA-Binding Proteins* / metabolism
  • Deamination / genetics
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / enzymology
  • Epigenesis, Genetic / genetics*
  • Epigenomics / methods*
  • Gene Expression Regulation, Developmental
  • Gene Silencing / physiology
  • Genome / genetics
  • Hematopoiesis / genetics
  • Humans
  • Mice
  • Mice, Knockout
  • Mixed Function Oxygenases
  • Proto-Oncogene Proteins* / genetics
  • Proto-Oncogene Proteins* / metabolism
  • Tissue Distribution / genetics

Substances

  • Chromatin
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • TET1 protein, mouse
  • TET2 protein, human
  • Tet2 protein, mouse
  • 5-hydroxymethylcytosine
  • 5-Methylcytosine
  • Cytosine
  • DNA
  • Mixed Function Oxygenases
  • TET1 protein, human
  • Tet3 protein, mouse