Old friends form alliance against podocytes

Kidney Int. 2011 Dec;80(11):1117-9. doi: 10.1038/ki.2011.298.


Wang and colleagues identify the activation of Wnt signaling as an important downstream event in transforming growth factor-β-mediated podocyte injury. Supported by other recent studies, canonical Wnt signaling is emerging as a critical stress pathway in podocytes and may be exploited for therapeutic strategies in the treatment of glomerulopathies.

Publication types

  • Comment

MeSH terms

  • Animals
  • Podocytes / pathology*
  • Proteinuria / etiology*
  • Transforming Growth Factor beta1 / physiology*
  • Wnt Proteins / metabolism*
  • Wnt Signaling Pathway / physiology*
  • beta Catenin / metabolism*


  • CTNNB1 protein, mouse
  • Transforming Growth Factor beta1
  • Wnt Proteins
  • beta Catenin