The forkhead transcription factor FOXK2 promotes AP-1-mediated transcriptional regulation

Mol Cell Biol. 2012 Jan;32(2):385-98. doi: 10.1128/MCB.05504-11. Epub 2011 Nov 14.

Abstract

The transcriptional control circuitry in eukaryotic cells is complex and is orchestrated by combinatorially acting transcription factors. Forkhead transcription factors often function in concert with heterotypic transcription factors to specify distinct transcriptional programs. Here, we demonstrate that FOXK2 participates in combinatorial transcriptional control with the AP-1 transcription factor. FOXK2 binding regions are widespread throughout the genome and are often coassociated with AP-1 binding motifs. FOXK2 acts to promote AP-1-dependent gene expression changes in response to activation of the AP-1 pathway. In this context, FOXK2 is required for the efficient recruitment of AP-1 to chromatin. Thus, we have uncovered an important new molecular mechanism that controls AP-1-dependent gene expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Binding Sites
  • Cell Line
  • Chromatin / genetics
  • Chromatin / metabolism
  • Forkhead Transcription Factors / genetics
  • Forkhead Transcription Factors / metabolism*
  • Genome, Human
  • Humans
  • Protein Binding
  • RNA, Small Interfering / genetics
  • Transcription Factor AP-1 / genetics*
  • Transcription Factor AP-1 / metabolism
  • Transcriptional Activation*

Substances

  • Chromatin
  • Forkhead Transcription Factors
  • RNA, Small Interfering
  • Transcription Factor AP-1
  • interleukin binding factor