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Review
. 2011:5:445-54.
doi: 10.2147/DDDT.S12139. Epub 2011 Oct 19.

Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates

Maurizio Muratore  1 , Eugenio Quarta, Antonella Grimaldi, Fabio Calcagnile, Laura Quarta
Affiliations
Review

Clinical utility of clodronate in the prevention and management of osteoporosis in patients intolerant of oral bisphosphonates

Maurizio Muratore et al. Drug Des Devel Ther. 2011.

Abstract

Bisphosphonates have a long history in the treatment of osteoporosis and bone-related disease. This review focuses on the use of a specific nonaminobisphosphonate, clodronate, which appears to be much better tolerated than other bisphosphonates and free of high-risk contraindications. Specifically, this paper reviews its use in the prevention of osteoporosis in postmenopausal women, taking into account its tolerability profile and recent safety issues arising regarding the use of bisphosphonates.

Keywords: bisphosphonates; bone turnover; clodronate; menopause; osteoporosis; tolerability.

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Figures

Figure 1
Figure 1
Bisphosphonate pathway, and the genes involved in the effects of bisphosphonates on osteoclasts. © PharmGKB. Reproduced with permission from PharmGKB and Stanford University. Gong Li, Altman Russ B, Klein TE. Bisphosphonates pathway. Pharmacogenetics and genomics (2009).
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