Asymptomatic profound sinus bradycardia (heart rate ≤45) in non-small cell lung cancer patients treated with crizotinib

J Thorac Oncol. 2011 Dec;6(12):2135-7. doi: 10.1097/JTO.0b013e3182307e06.


Crizotinib, a dual MET/ALK inhibitor, is now in advanced clinical development for the treatment of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). We have observed several patients who developed profound but asymptomatic sinus bradycardia (HR ≤45) during the course of crizotinib treatment. Herein, we describe the clinical characteristics of three separate patients enrolled in the A8081001 trial (NCT00585195) who developed asymptomatic profound sinus bradycardia with their accompanying electrocardiogram tracings.

Publication types

  • Case Reports
  • Clinical Trial

MeSH terms

  • Adult
  • Aged, 80 and over
  • Asymptomatic Diseases*
  • Bradycardia / chemically induced*
  • Carcinoma, Non-Small-Cell Lung / drug therapy*
  • Crizotinib
  • Female
  • Humans
  • Lung Neoplasms / drug therapy*
  • Male
  • Middle Aged
  • Protein Kinase Inhibitors / adverse effects*
  • Protein Kinase Inhibitors / therapeutic use
  • Pyrazoles / adverse effects*
  • Pyrazoles / therapeutic use
  • Pyridines / adverse effects*
  • Pyridines / therapeutic use


  • Protein Kinase Inhibitors
  • Pyrazoles
  • Pyridines
  • Crizotinib

Associated data