International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels

Pharmacol Rev. 2012 Jan;64(1):1-15. doi: 10.1124/pr.111.005009. Epub 2011 Nov 16.

Abstract

Calcium-activated chloride channels (CaCCs) are widely expressed in various tissues and implicated in physiological processes such as sensory transduction, epithelial secretion, and smooth muscle contraction. Transmembrane proteins with unknown function 16 (TMEM16A) has recently been identified as a major component of CaCCs. Detailed molecular analysis of TMEM16A will be needed to understand its structure-function relationships. The role this channel plays in physiological systems remains to be established and is currently a subject of intense investigation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anoctamin-1
  • Chloride Channels / antagonists & inhibitors
  • Chloride Channels / biosynthesis
  • Chloride Channels / classification
  • Chloride Channels / physiology*
  • Electrophysiological Phenomena
  • Glycosylation
  • Humans
  • International Agencies
  • Neoplasm Proteins / antagonists & inhibitors
  • Neoplasm Proteins / biosynthesis
  • Neoplasm Proteins / classification
  • Neoplasm Proteins / physiology*
  • Organ Specificity
  • Phosphorylation
  • Protein Conformation
  • Terminology as Topic
  • Xenopus Proteins / antagonists & inhibitors
  • Xenopus Proteins / biosynthesis
  • Xenopus Proteins / classification
  • Xenopus Proteins / physiology*

Substances

  • ANO1 protein, human
  • ANO1 protein, mouse
  • Anoctamin-1
  • Chloride Channels
  • Neoplasm Proteins
  • Xenopus Proteins
  • xANO2 protein, Xenopus