[Reduced synthesis of coenzyme Q10 may cause statin related myopathy]

Ugeskr Laeger. 2011 Nov 14;173(46):2943-8.
[Article in Danish]


Statin treatment can cause muscular side effects. It has been suggested that the mechanism is reduced synthesis of coenzyme Q10 (coQ10) and a subsequent dysfunction of the respiratory chain. A literature review resulted in insufficient evidence supporting this theory. It is uncertain whether intramuscular levels of coQ10 and mitochondrial function are affected by statin therapy and whether the symptoms of myopathy can be alleviated with coQ10 supplementation. Nevertheless, due to a favourable safety profile, coQ10 can be tested in patients whose muscular symptoms cannot be managed otherwise.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Mitochondria, Muscle / drug effects
  • Mitochondria, Muscle / metabolism
  • Muscles / drug effects
  • Muscles / metabolism
  • Muscular Diseases / chemically induced*
  • Muscular Diseases / drug therapy
  • Risk Factors
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / biosynthesis
  • Ubiquinone / blood
  • Ubiquinone / metabolism


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Ubiquinone
  • coenzyme Q10