Power cut: inhibiting mitochondrial translation to target leukemia

Cancer Cell. 2011 Nov 15;20(5):555-6. doi: 10.1016/j.ccr.2011.10.028.


In this issue of Cancer Cell, Skrtic et al. demonstrate that inhibition of mitochondrial ribosomes with tigecycline, a known antimicrobial, selectively kills leukemia cells. This finding highlights the metabolic susceptibility of leukemia cells to mitochondrial translational inhibition and identifies a compound with significant efficacy in an in vivo preclinical model.

Publication types

  • Comment