Wnts need a p(assport)24 to leave the ER

EMBO Rep. 2011 Dec 1;12(12):1207-8. doi: 10.1038/embor.2011.222.

Abstract

Wnts are secreted through a dedicated exocytic pathway, which has been only partly characterized. Here, Palmer and colleagues comment on two recent reports by the groups of K. Basler and M. Boutros, respectively, in which they show that p24 proteins take part in this exocytic route and are required for Wnt exit from the ER to the Golgi.

Publication types

  • Comment

MeSH terms

  • Animals
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / metabolism*
  • Genetic Testing*
  • Genome, Insect / genetics*
  • Membrane Transport Proteins / metabolism*
  • RNA Interference*
  • Vesicular Transport Proteins / metabolism*
  • Wnt Proteins / metabolism*
  • Wnt1 Protein / metabolism*

Substances

  • Drosophila Proteins
  • Membrane Transport Proteins
  • Vesicular Transport Proteins
  • Wnt Proteins
  • Wnt1 Protein