Genome-wide analysis of yeast aging

Subcell Biochem. 2012;57:251-89. doi: 10.1007/978-94-007-2561-4_12.

Abstract

In the past several decades the budding yeast Saccharomyces cerevisiae has emerged as a prominent model for aging research. The creation of a single-gene deletion collection covering the majority of open reading frames in the yeast genome and advances in genomic technologies have opened yeast research to genome-scale screens for a variety of phenotypes. A number of screens have been performed looking for genes that modify secondary age-associated phenotypes such as stress resistance or growth rate. More recently, moderate-throughput methods for measuring replicative life span and high-throughput methods for measuring chronological life span have allowed for the first unbiased screens aimed at directly identifying genes involved in determining yeast longevity. In this chapter we discuss large-scale life span studies performed in yeast and their implications for research related to the basic biology of aging.

Publication types

  • Review

MeSH terms

  • Aging / genetics*
  • Aging / metabolism
  • Cell Division
  • Gene Expression Regulation, Fungal
  • Genome, Fungal*
  • Genomics* / methods
  • Genotype
  • Longevity / genetics
  • Microbial Viability
  • Phenotype
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / genetics*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Signal Transduction
  • Time Factors

Substances

  • Saccharomyces cerevisiae Proteins