Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions

Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61. doi: 10.1002/anie.201105901. Epub 2011 Nov 16.

Authors

Tim Geppert¹, Stefanie Bauer, Jan A Hiss, Elea Conrad, Michael Reutlinger, Petra Schneider, Martin Weisel, Bernhard Pfeiffer, Karl-Heinz Altmann, Zoe Waibler, Gisbert Schneider

Affiliation

¹ Eidgenössische Technische Hochschule (ETH) Zürich, Department of Chemistry and Applied Biosciences, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.

PMID: 22095772
DOI: 10.1002/anie.201105901

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Binding Sites
Computer Simulation
Crystallography, X-Ray
Drug Design
Humans
Hydrogen Bonding
Immunosuppressive Agents / chemistry*
Interferon-alpha / antagonists & inhibitors
Interferon-alpha / metabolism*
Magnetic Resonance Spectroscopy
Protein Interaction Maps
Protein Structure, Tertiary
Receptor, Interferon alpha-beta / antagonists & inhibitors
Receptor, Interferon alpha-beta / metabolism*
Small Molecule Libraries / chemistry*
Surface Plasmon Resonance

Substances

Immunosuppressive Agents
Interferon-alpha
Small Molecule Libraries
Receptor, Interferon alpha-beta