Antidiabetic effect of the total polyphenolic acids fraction from Salvia miltiorrhiza Bunge in diabetic rats

Phytother Res. 2012 Jun;26(6):944-8. doi: 10.1002/ptr.3654. Epub 2011 Nov 17.

Abstract

An investigation was made to evaluate the therapeutic potential of the total polyphenolic acids fraction (PAF) from Salvia miltiorrhiza Bunge in the type 2 diabetes mellitus rats model with an oral dose of 187 mg/kg for 28 days. The results showed that PAF induced a significant decrease in fasting blood glucose (FBG), fasting blood insulin (FINS), total cholesterol (TC), triglyceride (TG) and blood urea nitrogen (BUN), and an obvious increase in insulin sensitivity index (ISI) in diabetic rats induced by a high fat diet and a low dose of streptozocin (STZ). These results suggested that PAF has antidiabetic potential in vivo.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acids / chemistry
  • Administration, Oral
  • Animals
  • Blood Glucose / drug effects
  • Blood Urea Nitrogen
  • Diabetes Mellitus, Experimental / drug therapy
  • Diet, High-Fat / adverse effects
  • Drug Evaluation, Preclinical
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / pharmacology
  • Hypoglycemic Agents / administration & dosage
  • Hypoglycemic Agents / pharmacology*
  • Insulin / blood
  • Insulin Resistance
  • Male
  • Phenanthrolines / chemistry
  • Phenanthrolines / pharmacology
  • Polyphenols / chemistry
  • Polyphenols / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Salvia miltiorrhiza / chemistry*
  • Streptozocin / adverse effects

Substances

  • Acids
  • Blood Glucose
  • Drugs, Chinese Herbal
  • Hypoglycemic Agents
  • Insulin
  • Phenanthrolines
  • Polyphenols
  • dan-shen root extract
  • Streptozocin