Cerebrospinal fluid neuropeptide Y in Alzheimer's disease

Eur Neurol. 1990;30(4):207-10. doi: 10.1159/000117347.


The cerebrospinal fluid neuropeptide Y level was measured by radioimmunoassay in 20 patients with probable Alzheimer's disease and in 19 controls. The mean level was lower in patients (69.5 +/- 36.7 pg/ml) than in controls (103 +/- 21.8 pg/ml; p less than 0.001). Patients with a disease duration of greater than 2 years had cerebrospinal fluid neuropeptide Y levels lower than those with shorter disease duration (p less than 0.02). These results suggest that neuropeptide Y containing cells may be involved in Alzheimer's disease. No correlation was found between neuropeptide Y levels and degree of cognitive impairment or age at disease onset.

MeSH terms

  • Aged
  • Alzheimer Disease / cerebrospinal fluid*
  • Alzheimer Disease / psychology
  • Antibody Specificity
  • Female
  • Humans
  • Iodine Radioisotopes
  • Male
  • Middle Aged
  • Neuropeptide Y / cerebrospinal fluid*
  • Psychiatric Status Rating Scales
  • Radioimmunoassay


  • Iodine Radioisotopes
  • Neuropeptide Y