Pancreas preservation for pancreas and islet transplantation: a minireview

Transplant Proc. 2011 Nov;43(9):3398-401. doi: 10.1016/j.transproceed.2011.09.052.

Abstract

Pancreas preservation by cold storage using University of Wisconsin solution was the mainstay method used for pancreas transplantation during the past 2 decades. Other solutions, such as HTK, Celsior, and SCOT 15, could not demonstrate any advantage for short preservation periods. But the advent of clinical islet transplantation and the larger use of controlled non-heart-beating donors have prompted the transplantation community to develop methods for increasing pancreas graft quality while preventing ischemic reperfusion damages. Oxygenation by 1- or 2-layer methods during pancreas preservation, as well as the use of perfluorocarbons, might increase the islet yield. Based on the former methods, there is a renewed interest in machine perfusion and oxygenation in pancreas preservation for pancreas transplantation and islet preparation.

Publication types

  • Review

MeSH terms

  • Adenosine / pharmacology
  • Allopurinol / pharmacology
  • Glutathione / pharmacology
  • Humans
  • Insulin / pharmacology
  • Islets of Langerhans / cytology*
  • Islets of Langerhans Transplantation / instrumentation
  • Islets of Langerhans Transplantation / methods*
  • Organ Preservation
  • Organ Preservation Solutions / pharmacology
  • Oxygen / metabolism
  • Pancreas / pathology
  • Pancreas Transplantation / instrumentation
  • Pancreas Transplantation / methods*
  • Perfusion
  • Raffinose / pharmacology

Substances

  • Insulin
  • Organ Preservation Solutions
  • University of Wisconsin-lactobionate solution
  • Allopurinol
  • Glutathione
  • Adenosine
  • Raffinose
  • Oxygen