Skin tissue engineering--in vivo and in vitro applications

Florian Groeber; Monika Holeiter; Martina Hampel; Svenja Hinderer; Katja Schenke-Layland

doi:10.1016/j.cps.2011.09.007

Skin tissue engineering--in vivo and in vitro applications

Clin Plast Surg. 2012 Jan;39(1):33-58. doi: 10.1016/j.cps.2011.09.007.

Authors

Florian Groeber¹, Monika Holeiter, Martina Hampel, Svenja Hinderer, Katja Schenke-Layland

Affiliation

¹ Department of Cell and Tissue Engineering, Fraunhofer-Institute for Interfacial Engineering and Biotechnology (IGB), Nobelstrasse 12, 70569 Stuttgart, Germany.

PMID: 22099847
DOI: 10.1016/j.cps.2011.09.007

Abstract

Significant progress has been made over the years in the development of in vitro-engineered substitutes that mimic human skin, either to be used as grafts for the replacement of lost skin or for the establishment of human-based in vitro skin models. This review summarizes these advances in in vivo and in vitro applications of tissue-engineered skin. We further highlight novel efforts in the design of complex disease-in-a-dish models for studies ranging from disease etiology to drug development and screening.