[Flow Index Vascularization dynamics in the preovulatory phase of controlled ovarian hyperstimulation: profile and relationship with conception rate]

Gynecol Obstet Fertil. 2012 Feb;40(2):99-103. doi: 10.1016/j.gyobfe.2011.08.026. Epub 2011 Nov 17.
[Article in French]


Objectives: To study the evolution of subendometrial vascularization flow index (VFI) in controlled ovarian hyperstimulation (COH+IIU) cycles and compare its dynamic changes in pregnant and non pregnant women.

Patients and methods: This is a retrospective study on 61 couples. To determine the profile of IVF just before ovulation, patients had 3D-Power Doppler angiography (3D-PDA) in this precise preovulatory phase.

Results: We observed a decreasing profile of VFI in 52% (32/61) of the main group cycles, in 45% (14/31) of the subgroup with spontaneous peak of LH (luteinizing hormone), and in 60% (18/30) of the hCG (human chorionic gonadotropin) trigger subgroup. There were ten conceptions, (10/61, 16.4%), including eight (8/32, 30%) that were associated with a decreasing profile of VFI versus two (2/29, 7%) that were associated with an increasing profile (NS). In the detection of LH peak subgroup, we observed five conceptions (5/14, 36%) associated with a decreasing profile versus one conception (1/17, 6%) associated with an increasing profile of VFI (OR: 8.3; confidence interval [CI] 95%: 0.8-444; P=0.06 in favor of a of decreasing VFI profile). In the hCG subgroup, there were three conceptions in the decreasing VFI profile (3/18, 17%) and one conception with increasing VFI (1/12, 17%, P=0.6).

Discussion and conclusion: In controlled ovarian hyperstimulation, a decreasing VFI profile is more common compared to an increasing one. Such au profile seems to be associated with a higher conception rate in cycles with spontaneous LH surge.

MeSH terms

  • Adult
  • Angiography
  • Chorionic Gonadotropin / administration & dosage
  • Endometrium / blood supply*
  • Endometrium / diagnostic imaging
  • Female
  • Fertilization / physiology*
  • Humans
  • Luteinizing Hormone / blood
  • Middle Aged
  • Ovulation Induction*
  • Pregnancy
  • Retrospective Studies
  • Ultrasonography, Doppler


  • Chorionic Gonadotropin
  • Luteinizing Hormone