iNKTs foil fungi

Martin Prlic; Tobias M Hohl

doi:10.1016/j.chom.2011.11.003

iNKTs foil fungi

Cell Host Microbe. 2011 Nov 17;10(5):421-2. doi: 10.1016/j.chom.2011.11.003.

Authors

Martin Prlic¹, Tobias M Hohl

Affiliation

¹ Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. mprlic@fhcrc.org

Abstract

Fungal cell wall polysaccharides are potent inducers of immune responses. Cohen et al. (2011) demonstrate that innate recognition of fungal β-(1,3) glucan triggers effector functions of invariant natural killer T (iNKT) cells through indirect, cytokine-driven activation, a process that mediates optimal protection against the opportunistic mold Aspergillus fumigatus.

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