XCL1 and XCR1 in the immune system

Microbes Infect. 2012 Mar;14(3):262-7. doi: 10.1016/j.micinf.2011.10.003. Epub 2011 Oct 31.

Abstract

XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response. It has been also shown that XCL1 and XCR1 are constitutively expressed in the thymus and regulate the thymic establishment of self-tolerance and the generation of regulatory T cells. This review summarizes the expression and function of XCL1 and XCR1 in the immune system.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Chemokines, C / genetics
  • Chemokines, C / immunology*
  • Cytotoxicity, Immunologic
  • Dendritic Cells / immunology
  • Gene Expression Regulation / immunology
  • Humans
  • Receptors, Chemokine / immunology*
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / immunology*
  • Self Tolerance
  • Spleen / cytology
  • Spleen / immunology
  • T-Lymphocytes, Regulatory / immunology
  • Thymus Gland / cytology
  • Thymus Gland / immunology

Substances

  • Chemokines, C
  • Receptors, Chemokine
  • Receptors, G-Protein-Coupled
  • XC chemokine receptor 1, mouse
  • XCL1 protein, human
  • XCR1 protein, human
  • Xcl1 protein, mouse